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Arthrinok

“Arthrinok reduces excessive TNF-a, IL-6, and IL17 which cause auto-immune diseases including arthritis.” Prof. Dr. Pichaet Wiriyachitra Ph.D., F.R.A.C.I.

The APCODM research focuses on ways of balancing the immune system using products derived from natural plant extracts. Below are causes and symptoms of osteoarthritis and rheumatoid arthritis; and the efficacy of APCODM products in treating both.

Osteoarthritis is the most common form of arthritis and is the result of the wearing down of the protective articular cartilage, which covers the end of bones in major joints of the body such as the knees, hips and spine.

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As the cartilage degenerates, the body tries to repair itself and forms new bone growth known as bone spurs or ‘osteophytes’. The bone spurs cause pain when they rub against existing bones and tissues. As the cartilage degenerates and bone spurs form, there is a decrease in mobility in the joints and movement becomes painful. The formation of bone spurs also causes deformation of the joints where the combined outcome is restricted mobility in the joints and their inability to take the body’s weight causing instability.

The main cause of osteoarthritis is the natural aging process of the body and the general wear and tear of the joints. Excessive use of the joints may increase the advent of osteoarthritis. Genetics, or having suffered from other forms of arthritis, plays a part in the likelihood of one suffering from osteoarthritis. Although being overweight is not the main cause, it is a contributing factor that might trigger osteoarthritis.

Osteoarthritis usually begins with joint pains in the morning and when exercising. Other symptoms include slower movement and general pain in the joints, and hearing a grinding sound when moving the joints. There is also swelling in the tendons and tissues around the joints caused by the friction of bone spurs, which also leads to the weakening of the muscles around the joints. The main characteristic of this disease is the extreme loss of the articular cartilage due to the degeneration by key mediators in the body.

Therefore, the only way to decrease pain in the joints is to prevent the degeneration of the cartilage and decrease the inflammation of the joints, thus allowing them to work more effectively again.

Rheumatoid arthritis is an autoimmune and chronic disease in which the body’s immune system – which protects your health by attacking foreign substances like bacteria and viruses – mistakenly attacks your joints. The initial symptoms are pain and swelling in the joints, especially the fingers, feet and ankles. In serious cases, there will be major swelling and the bones will degrade until they become deformed, eventually leading to disability in chronic cases.

Volunteers who took 4 Arthrinok capsules per day for 15 days showed a decrease of TNF-a, IL-6, and IL-17 which lowers the severity of inflammation and is a remedy for arthritis.

Both osteoarthritis and rheumatoid arthritis are caused by the white blood cells’ over-releasing inflammatory mediators IL-1B, TNF-a, IL-6 and IL-17 that result in inflammation.

*A clinical study on the effects of Arthrinok capsules done at the Biomedical Technology Research Centre

Mangosteen is a tropical fruit. The fruit, fruit juice, rind, twig, and bark are used as medicine. It is also used for many conditions such as diarrhea, urinary tract infections (UTIs), gonorrhea, thrush, tuberculosis, menstrual disorders, cancer, osteoarthritis, and an intestinal infection called dysentery. It is also used for stimulating the immune system and improving mental, but so far, there isn’t enough scientific evidence to determine whether or not it is effective for any of them.

Centella asiatica, a perennial herb also known as gotu kola, produces fan-shaped, green leaves that are harvested and used for medicinal purposes. Native to China, Japan, India and Indonesia, the herb has a long history of use in these areas. Medical practitioners in the United States and Europe have recently taken an interest in the herb for its possible health benefits.

Sesamin, a phytoestrogen, or plant estrogen, is a lignan that can be found in the hulls of sesame seeds. Sesame seeds are the source of sesame seed oil and sesame lignan. Another lignan that can be obtained from sesame seeds is sesamolin. Sesamin, has been used for centuries, but recently has become very popular due to the many benefits that can be derived from this natural supplement

The health benefits of guava include the treatment of diarrhea, dysentery, constipation, cough, cold, skin care, high blood pressure, weight loss and scurvy. What makes guava special is that protecting the fruit does not require excessive use of chemical pesticides as in the case of grapes, apple, and other so-called “exotic” fruits. It is one of the least chemically treated and sprayed fruits.

Soy protein is a protein that is isolated from soybean. It is made from soybean meal that has been dehulled and defatted. Dehulled and defatted soybeans are processed into three kinds of high protein commercial products : soy flour, concentrates, and isolates. Soy protein isolate has been used since 1959 in foods for its functional properties. Recently, soy protein popularity has increased due to its use in health food products, and many countries allow health claims for foods rich in soy protein.

Mr. Sampan Saleepalin (a 62 year old lecturer) – Ostheoarthritis

In the beginning of 2014, I started to feel pain in my knees and was having difficulty walking, especially going up and down the stairs. The pain prevented me from sleeping properly so I took pain killers. X-ray results later showed that I had osteoarthritis. Initially, my left knee was in worse condition than my right. After taking conventional medicine, I saw no improvement in my condition. My right knee became worse than my left. Then I began to feel sharp pains in my back so I had an MRI scan and discovered that I had a trapped sacral nerve. Because of this, I had to take more medicines and do physiotherapy for four to five months. Still, the symptoms remained and sometimes I needed injections to relieve the pain.

I was taking more than 10 pills a day with no end in sight. I became worried about the possible side effects on my kidneys and liver, so I decided to search for alternative methods on the Internet where I discovered BIM capsules. I found a lot of scientific research results showing that use of the capsules had no side effects, that they were safe, and that they were produced from natural plant extracts. So I decided to start taking BIM capsules in September 2014. I was able to observe that after just six days, I felt less pain in my legs and was able to walk up and down the stairs without using the hand rail. After three weeks, I no longer showed outward signs of osteoarthritis. After four months of taking BIM capsules, I felt that my left knee had improved by about 90%, my right knee by about 80%, and I no longer suffered from lower back pains.

Mrs. Wipa Ketsara (67 years old) – Ostheoarthritis

I had osteoarthritis for 4 – 5 years in both knees but it was worse in the left knee. I felt pain deep inside my knees, which were inflamed. The back of my knee joints were also swollen with fluid retention, the size of an egg, which I had drained twice but it came back both times. I had difficulty getting in and out of the car and getting up without assistance after sitting down. When moving my legs or massaging my knees, I heard a cracking sound.

In 2013, my daughter introduced me to BIM capsules, and after taking the capsules for 2 weeks I felt a little better, with less pain and swelling in my knees. After 2 months, my knees improved by about 90%. I regained mobility in my knees and I could walk easily again and the fluid retention also disappeared. After taking BIM capsules for 2 years, I had no pain in my knees and felt completely recovered.

Mrs. Thong Santhong (76 years old) – Ostheoarthritis

Ten years ago while gardening, I felt awful pain in my left knee and had to be taken to the hospital. I was diagnosed with osteoarthritis and calcification of my knee joints. The doctor injected lubrication fluid into my knees so that I could walk again. Later on though, the pain in my knees returned and I had to use a walking stick for several years. I also had to sleep on the ground floor as going up the stairs became impossible for me. I needed help to get out of a chair and could only walk short distances without pain in my knees. Both of my knees also made cracking noises when I moved so that every morning and evening I had to have a knee and leg massage. If I wanted to stretch my legs or bend my knees, I had to do it slowly and use my hands to help move my legs. I also began to get pain on my shoulders from using a walking stick and relying on my arms more.

In the beginning of 2013, while waiting to have a knee operation, my daughter introduced me to BIM capsules. After 2 – 3 months of taking the capsules, I could walk with less pain, go up and down the stairs, do household chores, ride a motorcycle again, and even walk 1 kilometer to my daughter’s house. By May that same year, I no longer experienced knee pain except a little stiffness in my legs. Apart from the improvements in my arthritis, my blood pressure and cholesterol levels went down, so the doctor also reduced my medication for these. After taking BIM capsules for one and a half years, I have regained full mobility and can even run to answer the phone now!

Mrs. Prapa Bunnag (64 years old) – Ostheoarthritis

I used to have swollen, painful knees for six years. I had difficulty going up and down the stairs; having to do so, I needed to do one step at a time. I also had to sit on a chair to put on trousers, but could not sit on the floor or do any exercise. I could not sleep at times due to the pain in my knees. I was diagnosed with osteoarthritis and not having enough lubrication fluid in my knee joints. I went for massages, took painkillers, and wore a knee support. I was worried about the side effects of the pain killers so I stopped taking them and began to have physiotherapy heat treatment every other day for many months to try to relieve the pain, but my symptoms continued. When I went on holiday, I could not walk around sightseeing, as I had done in the past, which depressed me as previously, I enjoyed traveling and walking.

Then in August 2014 my son’s friend introduced BIM capsules to me. After six weeks of taking the capsules the swelling decreased. I could put on my trousers in a standing position, no longer needed knee supports, and could walk to the shops and even go jogging. By the end of the year, I was able to take a 10-day trip to Europe to visit all the attractions I wanted to see and even walked in the snow. After taking BIM capsules for a year, walking up the stairs became an easy task. Now, I am planning more overseas trips!

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