“Diabenok reduces excessive TNF-α, IFN-γ and IL-17 which is the cause type 1 and type 2 diabetes.” Prof. Dr. Pichaet Wiriyachitra Ph.D., F.R.A.C.I.

Looking at the causes and symptoms of diabetes and the efficacy of BIM products:

Proven to effectively reduce the secretion of TNF-α, IFN-y and IL-17, Diabenok capsule, is a dietary supplement developed from synergistic substances which are derived from extracts of mangosteen, black sesame, soy, Centellaasiatica and guava.

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In type 1 diabetes, the immune system which normally fights harmful bacteria or viruses – attacks and destroys the insulin-producing Beta cells in the pancreas (autoimmunity). This type of diabetes results from the loss of the insulin-producing beta cells produced by the pancreas, leading to insulin deficiency. Type 1 diabetes can be classified as an autoimmune disease in which the T-cells destroy the beta cells.

Type 2 diabetes is when the insulin receptors in the body cells do not respond properly to the insulin. Insulin is the substance that helps bring glucose, as a source of energy, to the cells in our bodies. Therefore, people who suffer from diabetes have high blood sugar (glucose) and ineffective insulin. If high blood sugar levels persist for a long time, this will damage blood vessels and nerve ending system. If diabetes is not properly treated it can lead to other diseases such as difficulty in the healing of wounds, cardiovascular disease, kidney problems, blurred vision and stroke.

The white blood cells of diabetic patients secrete too much TNF-α, IFN-ƴ and IL-17, creating an overbalance of immunity. In the case of type 1 diabetes. the oversupply of TNF-α and IFN-y destroys the beta cells in the pancreas, reducing the natural production of insulin. Due to the oversupply of TNF-α and IFN-y in type 2 diabetes, the body cells will resist the natural insulin in the body. The oversupply of IL-17 will empower the body’s auto-immunity, which in turn increases the severity of the diabetes and its associated symptoms.

Volunteers who took 4 Diabenok capsules per day for 15 days significantly lowered their TNF-α, lower INF-γ and lower IL-17.

A decrease of TNF-α, INF-γ and IL-17 reduces the severity of type 1 and type 2 diabetes. Diabenok also lowers cholesterol and blood pressure.

*Scientific study on the effects of Diabenok capsules done at the Biomedical Technology Research Centre

Mangosteen is a tropical fruit. The fruit, fruit juice, rind, twig, and bark are used as medicine. It is also used for many conditions such as diarrhea, urinary tract infections (UTIs), gonorrhea, thrush, tuberculosis, menstrual disorders, cancer, osteoarthritis, and an intestinal infection called dysentery. It is also used for stimulating the immune system and improving mental, but so far, there isn’t enough scientific evidence to determine whether or not it is effective for any of them.

Centella asiatica, a perennial herb also known as gotu kola, produces fan-shaped, green leaves that are harvested and used for medicinal purposes. Native to China, Japan, India and Indonesia, the herb has a long history of use in these areas. Medical practitioners in the United States and Europe have recently taken an interest in the herb for its possible health benefits.

Sesamin, a phytoestrogen, or plant estrogen, is a lignan that can be found in the hulls of sesame seeds. Sesame seeds are the source of sesame seed oil and sesame lignan. Another lignan that can be obtained from sesame seeds is sesamolin. Sesamin, has been used for centuries, but recently has become very popular due to the many benefits that can be derived from this natural supplement

The health benefits of guava include the treatment of diarrhea, dysentery, constipation, cough, cold, skin care, high blood pressure, weight loss and scurvy. What makes guava special is that protecting the fruit does not require excessive use of chemical pesticides as in the case of grapes, apple, and other so-called “exotic” fruits. It is one of the least chemically treated and sprayed fruits.

Soy protein is a protein that is isolated from soybean. It is made from soybean meal that has been dehulled and defatted. Dehulled and defatted soybeans are processed into three kinds of high protein commercial products : soy flour, concentrates, and isolates. Soy protein isolate has been used since 1959 in foods for its functional properties. Recently, soy protein popularity has increased due to its use in health food products, and many countries allow health claims for foods rich in soy protein.

Mr. Kode Musa – Diabetes

I had been suffering from diabetes for 22 years. My initial symptoms were weight loss, weakness, always being thirsty and frequent urination. I was diagnosed with diabetes having a blood sugar level of 180 mg/dL, so I began to take medication for diabetes. However, my health continued to deteriorate, I started having stomach ulcers and suffered from high blood pressure and high cholesterol levels. My diabetes became worse and my kidneys began to fail that I had to start having insulin injections. I was later introduced to Diabenok and began to take Diabenok capsules (one in the morning and one before bed) along with my diabetes medications. After four to five months, my blood sugar level was down to 106 mg/dL and I no longer needed insulin injections. My complexion also improved and got my healthy color back again.

Kanchana Ritthem – Diabetes

Four years ago, I felt weak, dizzy and lethargic, and needed to urinate about ten times during the night. I could not control my bladder and had infection in my urinary tract. If I did not eat regularly, I would feel dizzy and start to perspire. I often get a blurry vision in my left eye. When I drive, I feel so tired that I have to pull over and take a nap. Last year I started to have numbness in my hands and left leg. These symptoms would last for two to three days at a time that I became afraid I would end up paralyzed. I was diagnosed with diabetes and I was given medication as my blood sugar level was over 100 mg/dL. After sometime, my blood sugar was still between 120-180 mg/dL, and I still feel dizzy and lethargic. I also had to urinate five to six times every night. After watching a TV program about Diabenok I decided to try it. I started taking Diabenok capsules in May 2013 (two in the morning and two before bed) along with my diabetes medication, and after just three to four days, I felt more energetic and my vision improving. After two weeks, I felt stronger with none of the numbness in my fingers and toes, I could control urination (only once or twice at night), and I was also able to drive again. If I ate at irregular hours, I no longer suffer from dizziness and perspiration. After taking Diabenok for one month my blood sugar level was down to 107 mg/dL.

Mr. Kriengkrai Maiket – Diabetes

At the end of 2011, I had a wound on my second toe that would not heal. The wound had become so bad the following year that I was admitted to the hospital. The underlying problem with my wound was said to be diabetes, with a blood sugar level of over 200 mg/dL. I had to start having insulin injections every day. The wound was black and had a bad odor which had spread to the other toes so that three of them eventually got removed. I was seriously ill with my weight down to 39 kg, and had to be fed intravenously. After seven months, I was discharged from the hospital and told to rest at home as I was very weak and one of my toes got re-infected. I discovered Diabenok and began taking six capsules a day. My appetite returned and after a month the re-infected wound on my toe started to improve and began to feel more energetic. After two to three months, the wound on my toe cleared up. I felt a lot better after four months with Diabenok that I reduced my intake to two capsules in the morning and two before bedtime. In April 2013, my blood sugar level had reduced to 110 mg/dL and weight had increased to 71 kg.

Mrs. Somboon Chomsaengkaew – Diabetes

I was diagnosed with diabetes since 1999, and in 2009, I had to start having insulin injections. In 2011, I had problems with my kidneys and suffered from macular degradation (impaired vision) that led me to undergo eye laser treatment. I also heard a grinding sound in my ears and both my hands and feet felt numb. I felt no pain even when my toe nail got pierced and bled. I also felt very lethargic and I had to sleep every afternoon. In the beginning of 2012, I’ve learned about Diabenok capsules and started taking them with my insulin injections. After just three days, the grinding sound in my ears decreased and began to regain feeling in my hands and feet. My blood sugar level was lower after 15 days and no longer felt any numbness or lethargy. After two months, both my blood pressure and blood sugar levels came down and I was able to reduce my dosage of insulin. Fourteen months later with Diabenok, my blood pressure and blood sugar levels were back to normal and my insulin dosage was further reduced. My doctor also decreased the frequency of my eye checkups from every three months to every six months. By the end of 2013, I felt much healthier and was able to exercise walking 2 km per day. In February 2014, my blood sugar level was just 101 mg/dL, so my doctor stopped the insulin injections and just prescribed oral diabetic medication. My kidneys were also improving and I only had to go for my eye appointments every eight months. I now take two Diabenok capsules before bed.

During the last decades, development of specific agents affecting T helper cell sub-populations, i.e., Th1, Th2 and Th17, differentiation has drawn special attention. Many natural products were reported as a good agent for modulating the immune response by regulating of the differentiation of T helper cell sub-populations. These products are potential to be the immunemodulators for treatment of various diseases including infectious diseases, cancers, autoimmune diseases and also arthritis.

In this study, we aim to study the immunomodulatory effects of the Operation BIM product. We investigate the possible effect of an Operation BIM product on the controlling of T helper cell sub-population differentiation. Click here to download the PDF.

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